We present a case of severe stenosis of the tibioperoneal trunk treated under angiographic and intravascular ultrasound (IVUS) guidance. In this case, angiography significantly under-estimated the true vessel size by 33.6% and failed to identify the presence of dissections when compared to IVUS. The lack of precision imaging may be one mechanism that explains the failure of some drug-coated balloons in below-the-knee interventions and why ~20% of drug-eluting stents fail to maintain patency at 1-year follow-up. Furthermore, under-estimating the number and severity of dissections by angiography may have significant implications on the outcome of an intervention.
Angiography has been shown to be a suboptimal imaging modality to identify intraluminal arterial pathology. Angiography under-estimates the presence of thrombus and calcium, vessel size, stent expansion, stent apposition, presence and severity of dissections, and true extent of disease.1-8 Multiple treatment modalities have been proposed to treat infrapopliteal disease. Angioplasty (PTA) carries overall poor results with reduced patency at 1 year.9 Also, patency is not improved over PTA with the use of bare-metal stenting (BMS)10 or the In-Pact or Biolux- PII drug-coated balloon (DCB).11,12 Drug-eluting stent (DES) implantation showed significantly better patency than PTA and/ or BMS at 1-year follow-up. However, despite very short lesions, these studies showed ~20% restenosis rate with DES.13-15
There are many factors that could potentially affect restenosis in infrapopliteal disease, including recoil, negative remodeling, and smooth muscle cell proliferation. Vessel wall stretch – and to a lesser extent, plaque compression – are the main mechanisms to achieve acute lumen gain.16 Vessel stretching quite often leads to dissection. In the case of drug-eluting devices, adequate drug delivery to prevent smooth muscle cell proliferation is a key to improve patency. The ability of the drug to reach the vessel wall is a critical first step. From there, the drug has to penetrate the vessel wall at a sufficient concentration and depth to have a critical therapeutic concentration. Therefore, adequate sizing of the balloon or the stent to the vessel wall becomes an additional critical step in endovascular procedures to ensure proper drug uptake.
We present a case of a tibioperoneal trunk (TPT) stenosis treated as part of the currently enrolling iDissection below-the-knee (BTK) feasibility study. This prospective study is evaluating the pattern of dissections in infrapopliteal disease based on the iDissection classification17 with IVUS, and determining the adequacy of angiography in achieving optimal balloon and stent sizing. Our patient presented with limiting claudication and was found to have multivessel tibial disease (90% right TPT and 90% proximal right anterior tibialis focal disease). We elected to treat the right TPT, as this was felt to be sufficient to take care of his symptoms. As part of the iDissection BTK protocol, angiography was performed to identify the worst lesion severity. IVUS was then performed and reference vessel diameter was measured from the external elastic lamina (EEL) to EEL and internal elastic lamina (IEL) to IEL. Using a 5.0 x 20 mm Emerge balloon (Boston Scientific), the lesion was treated with up to 12 atm of pressure for 180 seconds. IVUS was then repeated. The intention was to do primary stenting on this vessel to reduce the chance of restenosis. Based on sizes obtained from the IVUS, a 4.0 x 18 mm Onyx stent (Medtronic) – the largest coronary stent we had on the shelf – was placed and postdilated with a 5 x 20 mm Emerge balloon up to 14 atm.
Images were adjudicated by the quantitative vascular lab at the Midwest Cardiovascular Research Foundation using Echoplaque software (INDEC Systems) for IVUS analysis and CAAS software (Pie Medical Imaging) for angiographic analysis. The presence of dissection was then additionally adjudicated independently by the core lab using the NHLBI classification for angiographically visible dissections18 and the iDissection classification17 for IVUS-visible dissections.
Figure 1 illustrates the quantitative angiographic reading of the reference vessel diameter, which measured at 3.32 mm. Figure 2 illustrates the IVUS measurements and presence of dissections. The vessel diameter from EEL to EEL measured at a mean of 6.4 mm and from IEL to IEL at 5 mm. When compared to the IEL to IEL diameters, angiography under-estimated the lumen size by 33.6%.
If the PTA balloon was sized based on EEL to EEL diameter for an optimal vessel stretching, then it would have been under-sized by 48.1%. Furthermore, the angiogram did not demonstrate any dissection, whereas two type A1 dissections were noted using IVUS (intimal tear and <180° in circumference). After stenting, the lumen diameter by IVUS was 5 mm (Figure 2) and full stent expansion and apposition were noted. Patient did well, with no complications.
In this case, we illustrate the inadequacy of angiography for sizing infrapopliteal vessels and for identifying dissections. The large magnitude of the discrepancy in vessel diameter and in identifying dissections by angiography is well illustrated in this case report. This may be one mechanism that explains the failure of some BTK interventions to reduce late lumen loss in well-designed randomized trials.11,12 This may also explain why ~20% of DES cases fail to maintain patency at 1-year follow-up. Although other mechanisms such as severe calcification and medial calcinosis in the tibials may be responsible for this lack of effectiveness, we believe that precision imaging is critical in accurately sizing the vessel, properly identifying dissections, and directing the choice of treatment.
Disclosure: The authors have completed and returned the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr Shammas discloses educational and research grants from Intact Vascular, Philips, Boston Scientific, and Bard. Dr Armstrong is on the advisory board for Intact Vascular and reports educational grants from Philips. The remaining authors report no conflicts of interest regarding the content herein.
The authors report that patient consent was provided for publication of the images used herein.
Manuscript submitted November 1, 2018, and accepted November 16, 2018.
Address for correspondence: Nicolas W. Shammas, MD, MS, EJD, FACC, FSCAI, FSVM, Midwest Cardiovascular Research Foundation, 1622 E. Lombard Street, Davenport, IA 52803. Email: email@example.com
1. Mintz GS, Popma JJ, Pichard AD, et al. Patterns of calcification in coronary artery disease.A statistical analysis of intravascular ultrasound and coronary angiography in 1155 lesions. Circulation. 1995;91(7):1959-1965.
2. Kashyap VS, Pavkov ML, Bishop PD, et al. Angiography underestimates peripheral atherosclerosis: lumenography revisited. J Endovasc Ther. 2008;15(1):117-125.
3. Shammas NW, Dippel EJ, Shammas G, et al. Dethrombosis of the lower extremity arteries using the power-pulse spray technique in patients with recent onset thrombotic occlusions: results of the DETHROMBOSIS registry. J Endovasc Ther. 2008;15(5):570-579.
4. Arthurs ZM, Bishop PD, Feiten LE, et al. Evaluation of peripheral atherosclerosis: a comparative analysis of angiography and intravascular ultrasound. J Vasc Surg. 2010;51(4):933-939.
5. Korogi Y, Hirai T, Takahashi M. Intravascular ultrasound imaging of peripheral arteries as an adjunct to balloon angioplasty and atherectomy. Cardiovasc Intervent Radiol. 1996;19(1):1-9.
6. Katzen BT, Benenati JF, Becker GJ, Zemel G. Role of intravascular ultrasound in peripheral atherectomy and stent deployment (Abstr). Circulation. 1991;84(Suppl II):II-542.
7. Shammas NW, Torey JT, Shammas WJ, Jones-Miller S, Shammas GA. Intravascular ultrasound assessment and correlation with angiographic findings demonstrating femoropopliteal arterial dissections post atherectomy: results from the iDissection study. J Invasive Cardiol. 2018;30(7):240-244.
8. Cavaye DM, Diethrich EB, Santiago OJ, et al. Intravascular ultrasound imaging: an essential component of angioplasty assessment and vascular stent deployment. Int Angiol. 1993;12(3):214-222.
9. Mustapha JA, Finton SM, Diaz-Sandoval LJ, Saab FA, Miller LE. Percutaneous transluminal angioplasty in patients with infrapopliteal arterial disease: systematic review and meta-analysis. Circ Cardiovasc Interv. 2016;9(5):e003468.
10. Wu R, Yao C, Wang S, et al. Percutaneous transluminal angioplasty versus primary stenting in infrapopliteal arterial disease: a meta-analysis of randomized trials. J Vasc Surg. 2014;59(6):1711-1720.
11. Zeller T, Baumgartner I, Scheinert D, et al; for the IN.PACT DEEP Trial Investigators. Drug-eluting balloon versus standard balloon angioplasty for infrapopliteal arterial revascularization in critical limb ischemia: 12-month results from the IN.PACT DEEP randomized trial. J Am Coll Cardiol. 2014;64(15):1568-1576.
12. Zeller T, Beschorner U, Pilger E, et al. Paclitaxel-coated balloon in infrapopliteal arteries: 12-month results from the BIOLUX P-II randomized trial (BIOTRONIK'S-first in man study of the Passeo-18 LUX drug releasing PTA balloon catheter vs. the uncoated Passeo-18 PTA balloon catheter in subjects requiring revascularization of infrapopliteal arteries). JACC Cardiovasc Interv. 2015;8(12):1614-1622.
13. Rastan A, Tepe G, Krankenberg H, et al. Sirolimus-eluting stents vs. bare-metal stents for treatment of focal lesions in infrapopliteal arteries: a double-blind, multi-centre, randomized clinical trial. Eur Heart J. 2011;32(18):2274-2281.
14. Bosiers M, Scheinert D, Peeters P, et al. Randomized comparison of everolimus-eluting versus bare-metal stents in patients with critical limb ischemia and infrapopliteal arterial occlusive disease. J Vasc Surg. 2012;55(2):390-398.
15. Scheinert D, Katsanos K, Zeller T, et al. A prospective randomized multicenter comparison of balloon angioplasty and infrapopliteal stenting with the sirolimus-eluting stent in patients with ischemic peripheral arterial disease: 1-year results from the ACHILLES trial. J Am Coll Cardiol. 2012;60(22):2290-2295.
16. Baptista J, di Mario C, Ozaki Y, et al. Impact of plaque morphology and composition on the mechanisms of lumen enlargement using intracoronary ultrasound and quantitative angiography after balloon angioplasty. Am J Cardiol. 1996;77(2):115-121.
17. Shammas NW, Torey JT, Shammas WJ. Dissections in peripheral vascular interventions: a proposed classification using intravascular ultrasound. J Invasive Cardiol. 2018;30(4):145-146.
18. Rogers JH, Lasala JM. Coronary artery dissection and perfora- tion complicating percutaneous coronary intervention. J Invasive Cardiol. 2004;16(9):493-499.